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Relationship between anal pressure and anodermal blood flow. To learn more about Healthwise, visit Healthwise. Efficacy and safety of botulinum toxin A injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure: A prospective randomized study. Keywords: Anal fissure, chronic, botulinum toxin, sphincterotomy. Anal fissure and botox and treatment of anal fissure. Botulinum toxin: chemistry, pharmacology, toxicity, and immunology. Aliment Pharmacol Ther.