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Following radiation treatment for cancer, you should be checked on a regular basis by your radiation oncologist for recurring and new cancers. Learn about clinical trials at MD Anderson and search our treatment for anal cancer for open studies. Cancer Moonshots. There is a surgical treatment called abdominoperineal resection APR. Almost all cases of anal cancer are caused by human papillomavirus HPV infection, for which a safe and effective vaccine currently exists. Gardasil 9 prescribing information. Be sure to tell the health care team if you are experiencing a problem.